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Original Research (Original Article) Open Access


Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.

Onyebuchi Obia, Chinomso Ojiugo Ogwa, Sunday Ogbu Ojeka, Austin Azubuike Ajah, Arthur Nwafor Chuemere.

Abstract
One of the classical features of diabetes mellitus is weight loss which when excessive may be embarrassing to patients. The rising prevalence of the disease in developing countries coupled with its high cost of management is of great concern. The study is aimed at determining the effect of honey on the body weight of of glibenclamide treated alloxan induced diabetic rats. A total of 20 male wistar rats weighing 200 - 250g were obtained and divided into four groups of 5 rats each. Diabetes was induced in the animals by intraperitoneally injecting 100mg/kg of 2% alloxan solution. Each animal was weighed before and after experiment and recorded accordingly. The animals were respectively administered the following; group 1 received distilled water as 5.0ml/kg/day, group 2 received 5.0ml/kg/day of 50% honey, group 3 received 5.0ml/kg/day of 50% honey together with 0.6mg/kg/day of glibenclamide, group 4 received glibenclamide alone (0.6mg/kg/day). The animals were treated for 4weeks. The present study showed that addition of honey to glibenclamide in the treatment of alloxan diabetic rats significantly reduced weight loss associated with glibenclamide treatment alone. This is due to possible honey.induced pancreatic beta cell regeneration.

Key words: Honey, body weight, glibenclamide, diabetic.


 
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How to Cite this Article
Pubmed Style

Obia O, Ogwa CO, Ojeka SO, Ajah AA, Chuemere AN. Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.. J Apither. 2016; 1(1): 33-35. doi:10.5455/ja.20160711115722


Web Style

Obia O, Ogwa CO, Ojeka SO, Ajah AA, Chuemere AN. Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.. http://www.japitherapy.com/?mno=229777 [Access: December 18, 2017]. doi:10.5455/ja.20160711115722


AMA (American Medical Association) Style

Obia O, Ogwa CO, Ojeka SO, Ajah AA, Chuemere AN. Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.. J Apither. 2016; 1(1): 33-35. doi:10.5455/ja.20160711115722



Vancouver/ICMJE Style

Obia O, Ogwa CO, Ojeka SO, Ajah AA, Chuemere AN. Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.. J Apither. (2016), [cited December 18, 2017]; 1(1): 33-35. doi:10.5455/ja.20160711115722



Harvard Style

Obia, O., Ogwa, C. O., Ojeka, S. O., Ajah, A. A. & Chuemere, A. N. (2016) Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.. J Apither, 1 (1), 33-35. doi:10.5455/ja.20160711115722



Turabian Style

Obia, Onyebuchi, Chinomso Ojiugo Ogwa, Sunday Ogbu Ojeka, Austin Azubuike Ajah, and Arthur Nwafor Chuemere. 2016. Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.. Journal of Apitherapy, 1 (1), 33-35. doi:10.5455/ja.20160711115722



Chicago Style

Obia, Onyebuchi, Chinomso Ojiugo Ogwa, Sunday Ogbu Ojeka, Austin Azubuike Ajah, and Arthur Nwafor Chuemere. "Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.." Journal of Apitherapy 1 (2016), 33-35. doi:10.5455/ja.20160711115722



MLA (The Modern Language Association) Style

Obia, Onyebuchi, Chinomso Ojiugo Ogwa, Sunday Ogbu Ojeka, Austin Azubuike Ajah, and Arthur Nwafor Chuemere. "Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.." Journal of Apitherapy 1.1 (2016), 33-35. Print. doi:10.5455/ja.20160711115722



APA (American Psychological Association) Style

Obia, O., Ogwa, C. O., Ojeka, S. O., Ajah, A. A. & Chuemere, A. N. (2016) Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.. Journal of Apitherapy, 1 (1), 33-35. doi:10.5455/ja.20160711115722





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