E-ISSN 2474-137X |

Original Research (Original Article) Open Access


Alteration of PUMA gene expression in mice by royal jelly and green tea.

Wael S. Abdel-Mageed, Rasha Fathy, Mohamed Othman.

Abstract
AIM: The purpose of this study examine whether the polymorphism in (TNF-α) gene correlated with activate p53 upregulated modulator of apoptosis (PUMA) gene consequential exposure to pesticides and the effects of green tea and royal jelly in rats. METHODS: Experimental groups were organized into 12 groups including 10 animals per each. Contain control group, pesticide group and the rest of groups were pesticide + protective. Blood samples were collected form rats before and after occupational exposure to pesticides for liver and kidney enzymes biochemical analysis, the polymorphism of the genes for TNF-α and PUMA were typed from genomic DNA and Allelic frequencies and carriage rates were compared between healthy and treated rats. The correlation between TNF-α and PUMA genotypes and the clinical characteristics of rats were also evaluated. RESULTS: Data statistical analysis for mitochondrial enzymes in our study showed a very highly significant (P>0.001) difference in the mean value of serum enzymes isolated from treatments groups with pesticides before and after Royal jelly and Green tea treatments. The results of restriction enzymes for TNF-α showed there are no different between negative control with and both of two protective agents in the results of restricted bands. But the results from PUMA showed a strong deferent between the treatments with royal jelly and green tea combined with pesticides. The royal jelly and green tea enhance the repair system enzymes to remedy the mutation that originated in DNA after exposure to pesticides. CONCLUSION: Our recent work provides direct evidence Royal jelly and Green tea could be affects on mechanism related to the repair system in cell to remedy the DNA mutation

Key words: PUMA, gene, expression, Royal jelly, Green tea.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Wael S. Abdel-Mageed
Articles by Rasha Fathy
Articles by Mohamed Othman
on Google
on Google Scholar
Article Statistics
 Viewed: 747
Downloaded: 244
Cited: 0

REFERENCES
1. Hancock DB, Martin ER, Mayhew GM, Stajich JM, Jewett R, Stacy MA, et al. Pesticide exposure and risk of Parkinson's disease: a family-based case-control study. BMC Neurol. 2008;8:6. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
2. Eskenazi B, Marks AR, Bradman A, Harley K, Barr DB, Johnson C, et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect. 2007;115(5):792-8. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
3. Gordon CJ, Ward WO. A multianalyte profile of serum proteins to screen for toxicological effects of anticholinesterase insecticides in the rat. Neurotoxicology. 2009;30(3):377-81. [DOI via Crossref]    [Pubmed]   
4. Ghazi AA, Hosseinpanah F, E MA, Ghazi S, Hedayati M, Azizi F. Effects of different doses of oral cholecalciferol on serum 25(OH)D, PTH, calcium and bone markers during fall and winter in schoolchildren. Eur J Clin Nutr. 2010;64(12):1415-22. [DOI via Crossref]    [Pubmed]   
5. Farre M, Fernandez J, Paez M, Granada L, Barba L, Gutierrez HM, et al. Analysis and toxicity of methomyl and ametryn after biodegradation. Anal Bioanal Chem. 2002;373(8):704-9. [DOI via Crossref]    [Pubmed]   
6. Wei G, Li Y, Wang X. Application of dispersive liquid-liquid microextraction combined with high-performance liquid chromatography for the determination of methomyl in natural waters. J Sep Sci. 2007;30(18):3262-7. [DOI via Crossref]    [Pubmed]   
7. Kohno K, Okamoto I, Sano O, Arai N, Iwaki K, Ikeda M, et al. Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages. Biosci Biotechnol Biochem. 2004;68(1):138-45. [DOI via Crossref]    [Pubmed]   
8. Guo H, Saiga A, Sato M, Miyazawa I, Shibata M, Takahata Y, et al. Royal jelly supplementation improves lipoprotein metabolism in humans. J Nutr Sci Vitaminol (Tokyo). 2007;53(4):345-8. [DOI via Crossref]   
9. Ye T, Zhen J, Du Y, Zhou JK, Peng A, Vaziri ND, et al. Green tea polyphenol (-)-epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis. PLoS One. 2015;10(3):e0119543. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Morin MP, Bedran TB, Fournier-Larente J, Haas B, Azelmat J, Grenier D. Green tea extract and its major constituent epigallocatechin-3-gallate inhibit growth and halitosis-related properties of Solobacterium moorei. BMC Complement Altern Med. 2015;15:48. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
11. Rahmani AH, Al Shabrmi FM, Allemailem KS, Aly SM, Khan MA. Implications of Green Tea and Its Constituents in the Prevention of Cancer via the Modulation of Cell Signalling Pathway. Biomed Res Int. 2015;2015:925640. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
12. Santander SP, Hernandez JF, Barreto CC, Masayuki A, MoinsTeisserenc H, Fiorentino S. Immunomodulatory effects of aqueous and organic fractions from Petiveria alliacea on human dendritic cells. Am J Chin Med. 2012;40(4):833-44. [DOI via Crossref]    [Pubmed]   
13. Balkwill F. TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev. 2006;25(3):409-16. [DOI via Crossref]    [Pubmed]   
14. Thichanpiang P, Wongprasert K. Green tea polyphenol epigallocatechin-3-gallate attenuates TNF-alpha-induced intercellular adhesion molecule-1 expression and monocyte adhesion to retinal pigment epithelial cells. Am J Chin Med. 2015;43(1):103-19. [DOI via Crossref]    [Pubmed]   
15. Nakano K, Vousden KH. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell. 2001;7(3):683-94. [DOI via Crossref]   
16. Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell. 2001;7(3):673-82. [DOI via Crossref]   
17. Ogaly HA, Khalaf AA, Ibrahim MA, Galal MK, Abd-Elsalam RM. Influence of green tea extract on oxidative damage and apoptosis induced by deltamethrin in rat brain. Neurotoxicol Teratol. 2015;50:23-31. [DOI via Crossref]    [Pubmed]   
18. Danial NN, Korsmeyer SJ. Cell death: critical control points. Cell. 2004;116(2):205-19. [DOI via Crossref]   
19. Kanbur M, Eraslan G, Beyaz L, Silici S, Liman BC, Altinordulu S, et al. The effects of royal jelly on liver damage induced by paracetamol in mice. Exp Toxicol Pathol. 2009;61(2):123-32. [DOI via Crossref]    [Pubmed]   
20. Zhijian Y, Hui L, Weiming Y, Zhanzhou L, Zhong C, Jinxin Z, et al. Role of the Aspartate Transaminase and Platelet Ratio Index in Assessing Hepatic Fibrosis and Liver Inflammation in Adolescent Patients with HBeAg-Positive Chronic Hepatitis B. Gastroenterol Res Pract. 2015;2015:906026. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
21. Takaki-Doi S, Hashimoto K, Yamamura M, Kamei C. Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats. Acta Med Okayama. 2009;63(1):57-64. [Pubmed]   
22. Zhao G, Haskins N, Jin Z, N MA, Tuchman M, Shi D. Structure of N-acetyl-L-glutamate synthase/kinase from Maricaulis maris with the allosteric inhibitor L-arginine bound. Biochem Biophys Res Commun. 2013;437(4):585-90. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
23. Nasri H, Hajian S, Ahmadi A, Baradaran A, Kohi G, Nasri P, et al. Ameliorative effect of green tea against contrast-induced renal tubular cell injury. Iran J Kidney Dis. 2015;9(6):421-6. [Pubmed]   
24. Nomura S, Monobe M, Ema K, Matsunaga A, Maeda-Yamamoto M, Horie H. Effects of flavonol-rich green tea cultivar (Camellia sinensis L.) on plasma oxidized LDL levels in hypercholesterolemic mice. Biosci Biotechnol Biochem. 2016;80(2):360-2. [DOI via Crossref]    [Pubmed]   
25. Silici S, Ekmekcioglu O, Kanbur M, Deniz K. The protective effect of royal jelly against cisplatin-induced renal oxidative stress in rats. World J Urol. 2011;29(1):127-32. [DOI via Crossref]    [Pubmed]   
26. Kodai T, Umebayashi K, Nakatani T, Ishiyama K, Noda N. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chem Pharm Bull (Tokyo). 2007;55(10):1528-31. [DOI via Crossref]   
27. Das SK, M A, Subudhi M. Giant congenital melanocytic nevi: a case report. J Clin Diagn Res. 2013;7(1):154-5. [DOI via Crossref]   
28. Peng YH, Sweet DH, Lin SP, Yu CP, Lee Chao PD, Hou YC. Green tea inhibited the elimination of nephro-cardiovascular toxins and deteriorated the renal function in rats with renal failure. Sci Rep. 2015;5:16226. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
29. Safer AM, Hanafy NA, Bharali DJ, Cui H, Mousa SA. Effect of Green Tea Extract Encapsulated Into Chitosan Nanoparticles on Hepatic Fibrosis Collagen Fibers Assessed by Atomic Force Microscopy in Rat Hepatic Fibrosis Model. J Nanosci Nanotechnol. 2015;15(9):6452-9. [DOI via Crossref]    [Pubmed]   
30. Zhang Y, Wang X, Han L, Zhou Y, Sun S. Green tea polyphenol EGCG reverse cisplatin resistance of A549/DDP cell line through candidate genes demethylation. Biomed Pharmacother. 2015;69:285-90. [DOI via Crossref]    [Pubmed]   
31. Deb G, Thakur VS, Limaye AM, Gupta S. Epigenetic induction of tissue inhibitor of matrix metalloproteinase-3 by green tea polyphenols in breast cancer cells. Mol Carcinog. 2015;54(6):485-99. [DOI via Crossref]    [Pubmed]   
32. Spannhoff A, Kim YK, Raynal NJ, Gharibyan V, Su MB, Zhou YY, et al. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep. 2011;12(3):238-43. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
33. Chung MY, Mah E, Masterjohn C, Noh SK, Park HJ, Clark RM, et al. Green Tea Lowers Hepatic COX-2 and Prostaglandin E2 in Rats with Dietary Fat-Induced Nonalcoholic Steatohepatitis. J Med Food. 2015;18(6):648-55. [DOI via Crossref]    [Pubmed]   
34. Zhu K, Wang W. Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1. Tumour Biol. 2016;37(4):4373-82. [DOI via Crossref]    [Pubmed]   
35. Mack CM, Gordon CJ. Differential sensitivity to anticholinesterase insecticides in the juvenile rat: effects on thermoregulation. J Toxicol Environ Health A. 2007;70(5):439-44. [DOI via Crossref]    [Pubmed]   
36. Farrar MD, Nicolaou A, Clarke KA, Mason S, Massey KA, Dew TP, et al. A randomized controlled trial of green tea catechins in protection against ultraviolet radiation-induced cutaneous inflammation. Am J Clin Nutr. 2015;102(3):608-15. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   

How to Cite this Article
Pubmed Style

Abdel-Mageed WS, Fathy R, Othman M. Alteration of PUMA gene expression in mice by royal jelly and green tea.. J Apither. 2016; 1(1): 7-13. doi:10.5455/ja.20160504095722



Web Style

Abdel-Mageed WS, Fathy R, Othman M. Alteration of PUMA gene expression in mice by royal jelly and green tea.. www.scopemed.org/?mno=226341 [Access: October 22, 2017]. doi:10.5455/ja.20160504095722



AMA (American Medical Association) Style

Abdel-Mageed WS, Fathy R, Othman M. Alteration of PUMA gene expression in mice by royal jelly and green tea.. J Apither. 2016; 1(1): 7-13. doi:10.5455/ja.20160504095722



Vancouver/ICMJE Style

Abdel-Mageed WS, Fathy R, Othman M. Alteration of PUMA gene expression in mice by royal jelly and green tea.. J Apither. (2016), [cited October 22, 2017]; 1(1): 7-13. doi:10.5455/ja.20160504095722



Harvard Style

Abdel-Mageed, W. S., Fathy, R. & Othman, M. (2016) Alteration of PUMA gene expression in mice by royal jelly and green tea.. J Apither, 1 (1), 7-13. doi:10.5455/ja.20160504095722



Turabian Style

Abdel-Mageed, Wael S., Rasha Fathy, and Mohamed Othman. 2016. Alteration of PUMA gene expression in mice by royal jelly and green tea.. Journal of Apitherapy, 1 (1), 7-13. doi:10.5455/ja.20160504095722



Chicago Style

Abdel-Mageed, Wael S., Rasha Fathy, and Mohamed Othman. "Alteration of PUMA gene expression in mice by royal jelly and green tea.." Journal of Apitherapy 1 (2016), 7-13. doi:10.5455/ja.20160504095722



MLA (The Modern Language Association) Style

Abdel-Mageed, Wael S., Rasha Fathy, and Mohamed Othman. "Alteration of PUMA gene expression in mice by royal jelly and green tea.." Journal of Apitherapy 1.1 (2016), 7-13. Print. doi:10.5455/ja.20160504095722



APA (American Psychological Association) Style

Abdel-Mageed, W. S., Fathy, R. & Othman, M. (2016) Alteration of PUMA gene expression in mice by royal jelly and green tea.. Journal of Apitherapy, 1 (1), 7-13. doi:10.5455/ja.20160504095722





Most Viewed Articles
  • Welcome to Journal of Apitherapy
    Editor
    J Apither. 2016; 1(1): 1-1
    » Abstract & References » doi: 10.5455/ja.20160509012435

  • Honey and its uses in oral diseases- An overview
    Santosh R Patil, Ravi Kumar Gudipaneni
    J Apither. 2016; 1(1): 17-19
    » Abstract & References » doi: 10.5455/ja.20160428110757

  • The value of Mountain Sidr Honey in treating and controlling chronic constipation: A Prospective comparative study between Ziziphus honey and Lactulose in 1000 Saudi Arabian patients
    Bader Hamza Shirah, Hamza Asaad Shirah
    J Apither. 2016; 1(1): 2-6
    » Abstract & References » doi: 10.5455/ja.20160507094522

  • Wound healing with Apitherapy: A Review of the Effects of Honey
    Michael Malone, Gary Tsai
    J Apither. 2016; 1(1): 29-32
    » Abstract & References » doi: 10.5455/ja.20160620031837

  • Extraction and analysis of biologically active compounds in different Algerian honeys
    Hamza Belkhodja, Asmaa Belmimoun, Boumediene Meddah
    J Apither. 2016; 1(1): 14-16
    » Abstract & References » doi: 10.5455/ja.20160507094104

  • Health Benefits and Traditional Uses of Honey: A Review
    Menuka - Arawwawala, sujatha - Hewageegana
    J Apither. 2017; 2(1): 9-14
    » Abstract » doi: 10.5455/ja.20170208043727

  • Alteration of PUMA gene expression in mice by royal jelly and green tea.
    Wael S. Abdel-Mageed, Rasha Fathy, Mohamed Othman
    J Apither. 2016; 1(1): 7-13
    » Abstract & References » doi: 10.5455/ja.20160504095722

  • Bee venom apipuncture; a successful therapy for myofascial pain. A case based review
    Ibrahim Tekeoglu, Mehmet Akdogan, Suleyman Kaleli
    J Apither. 2016; 1(1): 20-22
    » Abstract & References » doi: 10.5455/ja.20160702123455

  • The effects of honey supplementation on Egyptian children with hepatitis A: A randomized double blinded placebo controlled pilot study
    Mamdouh Abdulmaksoud Abdulrhman, Rania Shatla, Sahar Mohamed
    J Apither. 2016; 1(1): 23-28
    » Abstract & References » doi: 10.5455/ja.20160702011113

  • Propolis as an alternative in prevention and control of dental cavity
    Brbara Soares Machado, Tarcyane Neves Pulcino, Ayalla Lima Silva, Diego Tadeu Melo, Renata Gomes Silva, Izabel Gomes Mendona
    J Apither. 2016; 1(2): 47-50
    » Abstract » doi: 10.5455/ja.20160726115117

  • Most Downloaded
  • Welcome to Journal of Apitherapy
    Editor
    J Apither. 2016; 1(1): 1-1
    » Abstract & References » doi: 10.5455/ja.20160509012435

  • Honey and its uses in oral diseases- An overview
    Santosh R Patil, Ravi Kumar Gudipaneni
    J Apither. 2016; 1(1): 17-19
    » Abstract & References » doi: 10.5455/ja.20160428110757

  • Wound healing with Apitherapy: A Review of the Effects of Honey
    Michael Malone, Gary Tsai
    J Apither. 2016; 1(1): 29-32
    » Abstract & References » doi: 10.5455/ja.20160620031837

  • Extraction and analysis of biologically active compounds in different Algerian honeys
    Hamza Belkhodja, Asmaa Belmimoun, Boumediene Meddah
    J Apither. 2016; 1(1): 14-16
    » Abstract & References » doi: 10.5455/ja.20160507094104

  • The value of Mountain Sidr Honey in treating and controlling chronic constipation: A Prospective comparative study between Ziziphus honey and Lactulose in 1000 Saudi Arabian patients
    Bader Hamza Shirah, Hamza Asaad Shirah
    J Apither. 2016; 1(1): 2-6
    » Abstract & References » doi: 10.5455/ja.20160507094522

  • Alteration of PUMA gene expression in mice by royal jelly and green tea.
    Wael S. Abdel-Mageed, Rasha Fathy, Mohamed Othman
    J Apither. 2016; 1(1): 7-13
    » Abstract & References » doi: 10.5455/ja.20160504095722

  • Bee venom apipuncture; a successful therapy for myofascial pain. A case based review
    Ibrahim Tekeoglu, Mehmet Akdogan, Suleyman Kaleli
    J Apither. 2016; 1(1): 20-22
    » Abstract & References » doi: 10.5455/ja.20160702123455

  • The effects of honey supplementation on Egyptian children with hepatitis A: A randomized double blinded placebo controlled pilot study
    Mamdouh Abdulmaksoud Abdulrhman, Rania Shatla, Sahar Mohamed
    J Apither. 2016; 1(1): 23-28
    » Abstract & References » doi: 10.5455/ja.20160702011113

  • Propolis as an alternative in prevention and control of dental cavity
    Brbara Soares Machado, Tarcyane Neves Pulcino, Ayalla Lima Silva, Diego Tadeu Melo, Renata Gomes Silva, Izabel Gomes Mendona
    J Apither. 2016; 1(2): 47-50
    » Abstract » doi: 10.5455/ja.20160726115117

  • Effect of honey on the body weight of glibenclamide treated alloxan induced diabetic rats.
    Onyebuchi Obia, Chinomso Ojiugo Ogwa, Sunday Ogbu Ojeka, Austin Azubuike Ajah, Arthur Nwafor Chuemere
    J Apither. 2016; 1(1): 33-35
    » Abstract & References » doi: 10.5455/ja.20160711115722

  • Most Cited Articles